À la fin de l’épisode, elle informe le Meredith sera à l’origine de l’innovation chirurgicale qui sauvera la vie de Megane Hunt, la sœur de Owen. Lucifer Morningstar has decided he's had enough of being the dutiful servant in Hell and decides to spend some time on Earth to better understand humanity. The presidential team asked him to become more involved in the project, but he initially refused the offer in an attempt to keep his promise to Meredith. She was cleared by Dr. Andrew Perkins only after she admitted her pregnancy and miscarriage. Carina had overheard her concerns and shared that she had been worried about Andrew for a while, having noticed signs of high highs and low lows in recent years. However, when George alerted the chief that Sadie did not seem to have much medical knowledge, she quit and asked Meredith to leave with her. Before she could elaborate, Jo called her about Alex assaulting Andrew. Meredith joined him in the hyperbaric chamber with Unwilling to explain the whole situation to the technicians through the phone to stop Andrew, Meredith had no choice but to focus on Gus and Alex. The three stayed friends, even taking in Meredith's dog, but Addison sometimes felt a tension between the two and realized that everybody knew Derek loved Meredith, except for Derek and Meredith.
As he lowered her down, she dropped into his arms and they almost shared a kiss until the power kicked back in. They wouldn’t give it to me.
Later, when Derek got shot, Meredith said that April didn't have the right to cry because of Derek, but she told Meredith that Reed, her best friend died. Derek was involved in a car accident with serious injuries. Par contre, quand elle voit qu'elle n'est pas mentionnée dans le rapport de l'essai clinique, appelé la méthode Shepherd, elle se met en colère. She returned later on after Meredith called her and told her Alex might be moving on, the same night that Alex slept with Lexie. Derek later learned that the federal team wanted him to run the project's advisory board. There is no sexual attraction between the two, as shown when Meredith sits in the bathroom and has a girl talk with Alex. Elle et Cristina apprennent des "trucs", Meredith en vient alors à la conclusion que si Ellis n'avait pas été sa mère, elle l'aurait aimée. He concluded by saying she was always welcome to visit once she had accepted his decision so that his kids could meet their Auntie Mer, adding that he hoped she wouldn't hate him too much. She told him she loved him and left to set the record straight.She immediately went to her attorney. When Derek was leaving to hand in his resignation to the White House, he told Meredith to stay and wait for him, just like when he left her at the house of candles so he could break up with Rose. Tom made Meredith wait in the waiting area so she made Taryn promise to text her updates. Together with Maggie, she ran some cognitive tests, which he failed miserably. Soon after, they got stuck together in an elevator on their way to the OR due to a power outage caused by the storm.Andrew and Meredith bond while stuck in an elevator.Meredith decides not to choose between the two men pursuing her just yet.With no cell phone connection, they tried to find a way out to no avail. Her supervisor She got in touch with a website that would publish her story and shared some titles she had thought of with Andrew, all of them insulting to the medical system. Dans l'épisode 17, Derek avoue qu'il a embrassé, Renee Collier, une de ses élèves, mais il s'est finalement rendu compte qu'il n'aime qu'une femme, et c'est Meredith, il lui dit un discours d'amour.
Andrew hated that she made a choice that could land her in jail and added to the possibility of her losing her license. She took him back to his room. When his cancer spread, he was put down and Meredith and Derek agreed to bury him in his favorite spot on Derek's land.
Meredith and Derek met Zola when she was brought to the hospital for an operation as part of Alex's program.
Ellis was conceived before Derek's death. Elle annonce ensuite à Derek qu'elle est enceinte. Meredith talked about Vincenzo with Alex and advised him to dig deeper before agreeing to fund the research, but hid her knowledge about his mental illness so as to not break Andrew's trust. Meredith toujours attachée à Derek, enchaîne les aventures d'un soir pour essayer de l'oublier. She then told him about her miscarriage. Après mûre réflexion, elle décide de donner un morceau de son foie à son père, pas pour lui, mais pour Lexie. Maggie and Amelia came to sit with her and Meredith vented her frustration about Andrew, who just didn't get her because he wasn't a parent himself. Meredith entre comme interne en première année de chirurgie à l'hôpital Seattle Grace. Conversation then came easier and Meredith told him about Maggie and her children and comforted him until he died with her by his side.On Christmas Eve, Jo and Alex invited Meredith for their classy NYE party. A mockumentary on a group of typical office workers, where the workday consists of ego clashes, inappropriate behavior, and tedium. Ainsi, après avoir bu, elle fait l'amour avec George avant d'éclater en sanglots. At work, Meredith made it clear to Nathan that she didn't want him to get too attached, which he assured her he wasn't. They were given a date to see a judge about the adoption after Alex went to the judge directly.
Back at home, Alex told Meredith about Bailey's decision to let him work in the clinic and that he supported that decision because his head wasn't in the game. He eventually chose Addison and Meredith was left heartbroken.
Cristina stayed at Meredith's house, both of the men away, and helped take care of baby Zola. Celle-ci prendra la défense de sa sœur, signalant à Teddy que celle-ci doit être honnête envers Owen et Amélia car Amélia est sa sœur. Meredith commence par faire un cauchemar où Derek meurt mais se réveille. Son téléphone sonne pendant le trajet, il l'attrape et comme il est au beau milieu d'une route, un camion le percute.